Knockdown of trem2 promotes proinflammatory microglia and inhibits glioma progression via the JAK2/STAT3 and NF-κB pathways

Abstract Background In the tumor immune microenvironment (TIME), triggering receptor expressed on myeloid cells 2 (trem2) is widely considered to be a crucial molecule on tumor-associated macrophages(TAMs). Multiple studies have shown that trem2 may function as an immune checkpoint in various malign...

Volledige beschrijving

Bibliografische gegevens

Hoofdauteurs:	Yunji Yan, Shengwei Bai, Hongxi Han, Junqiang Dai, Liang Niu, Hongyu Wang, Qiang Dong, Hang Yin, Guoqiang Yuan, Yawen Pan
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	BMC 2024-05-01
Reeks:	Cell Communication and Signaling
Onderwerpen:	Glioma Glioblastoma Microglia Trem2 protein Stat1 protein Microglial polarization
Online toegang:	https://doi.org/10.1186/s12964-024-01642-6
Tags:	Voeg label toe Geen labels, Wees de eerste die dit record labelt!