Opposite microglial activation stages upon loss of PGRN or TREM2 result in reduced cerebral glucose metabolism

Abstract Microglia adopt numerous fates with homeostatic microglia (HM) and a microglial neurodegenerative phenotype (MGnD) representing two opposite ends. A number of variants in genes selectively expressed in microglia are associated with an increased risk for neurodegenerative diseases such as Al...

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Autors principals:	Julia K Götzl, Matthias Brendel, Georg Werner, Samira Parhizkar, Laura Sebastian Monasor, Gernot Kleinberger, Alessio‐Vittorio Colombo, Maximilian Deussing, Matias Wagner, Juliane Winkelmann, Janine Diehl‐Schmid, Johannes Levin, Katrin Fellerer, Anika Reifschneider, Sebastian Bultmann, Peter Bartenstein, Axel Rominger, Sabina Tahirovic, Scott T Smith, Charlotte Madore, Oleg Butovsky, Anja Capell, Christian Haass
Format:	Artigo
Idioma:	Inglês
Publicat:	Springer Nature 2019-05-01
Col·lecció:	EMBO Molecular Medicine
Matèries:	disease‐associated and homeostatic microglial signatures microglia neurodegeneration progranulin TREM2
Accés en línia:	https://doi.org/10.15252/emmm.201809711
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