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Knockdown of trem2 promotes proinflammatory microglia and inhibits glioma progression via the JAK2/STAT3 and NF-κB pathways

Abstract Background In the tumor immune microenvironment (TIME), triggering receptor expressed on myeloid cells 2 (trem2) is widely considered to be a crucial molecule on tumor-associated macrophages(TAMs). Multiple studies have shown that trem2 may function as an immune checkpoint in various malign...

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Principais autores: Yunji Yan, Shengwei Bai, Hongxi Han, Junqiang Dai, Liang Niu, Hongyu Wang, Qiang Dong, Hang Yin, Guoqiang Yuan, Yawen Pan
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2024-05-01
Serier:Cell Communication and Signaling
Fag:
Glioma
Glioblastoma
Microglia
Trem2 protein
Stat1 protein
Microglial polarization
Online adgang:https://doi.org/10.1186/s12964-024-01642-6
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