Transcriptomic analysis of non-leukemic cell subsets in azacytidine-responsive AML highlights pathways associated with adhesion, platelet aggregation, and angiogenesis in mice and humans

Abstract Background Hypomethylating agents (HMAs), such as 5-azacytidine (AZA), are valuable treatment options for patients with acute myeloid leukemia (AML). Despite providing significant extensions in survival when used alone or in combination with BCL-2 inhibitors, resistance and eventual relapse...

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Hauptverfasser:	Nancy D. Ebelt, Suvithanandhini Loganathan, Lara C. Avsharian, Edwin R. Manuel
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2025-05-01
Schriftenreihe:	Molecular Medicine
Schlagworte:	Acute myeloid leukemia 5-azacytidine Hypomethylating agents Remission Relapse Transcriptomics
Online-Zugang:	https://doi.org/10.1186/s10020-025-01233-2
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