Re-sensitization of Mycobacterium smegmatis to Rifampicin Using CRISPR Interference Demonstrates Its Utility for the Study of Non-essential Drug Resistance Traits

A greater understanding of the genes involved in antibiotic resistance in Mycobacterium tuberculosis (Mtb) is necessary for the design of improved therapies. Clustered regularly interspaced short palindromic repeat interference (CRISPRi) has been previously utilized in mycobacteria to identify novel...

Полное описание

Библиографические подробности

Главные авторы:	Valwynne Faulkner, Adrienne Adele Cox, Shan Goh, Annelies van Bohemen, Amanda J. Gibson, Oliver Liebster, Brendan W. Wren, Sam Willcocks, Sharon L. Kendall
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Frontiers Media S.A. 2021-02-01
Серии:	Frontiers in Microbiology
Предметы:	antibiotic resistance tuberculosis CRISPRi mycobacteria rifampicin resistance
Online-ссылка:	https://www.frontiersin.org/articles/10.3389/fmicb.2020.619427/full
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