Phox2b mutation mediated by Atoh1 expression impaired respiratory rhythm and ventilatory responses to hypoxia and hypercapnia

Mutations in the transcription factor Phox2b cause congenital central hypoventilation syndrome (CCHS). The syndrome is characterized by hypoventilation and inability to regulate breathing to maintain adequate O2 and CO2 levels. The mechanism by which CCHS impact respiratory control is incompletely u...

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Hlavní autoři:	Caroline B Ferreira, Talita M Silva, Phelipe E Silva, Claudio L Castro, Catherine Czeisler, José J Otero, Ana C Takakura, Thiago S Moreira
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	eLife Sciences Publications Ltd 2022-11-01
Edice:	eLife
Témata:	hypercapnia hypoxia ventilation phox2b retrotrapezoid nucleus
On-line přístup:	https://elifesciences.org/articles/73130
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