Does Amifostine Reduce Metabolic Rate? Effect of the Drug on Gas Exchange and Acute Ventilatory Hypoxic Response in Humans

Amifostine is added to chemoradiation regimens in the treatment of many cancers on the basis that, by reducing the metabolic rate, it protects normal cells from toxic effects of therapy. We tested this hypothesis by measuring the metabolic rate (by gas exchange) over 255 min in 6 healthy subjects, a...

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Auteurs principaux:	Jaideep J. Pandit, Caroline Allen, Evelyn Little, Federico Formenti, Adrian L. Harris, Peter A. Robbins
Format:	Artigo
Langue:	Inglês
Publié:	MDPI AG 2015-04-01
Collection:	Pharmaceuticals
Sujets:	hypoxia hypercapnia ventilation ventilatory control chemoreflexes metabolism gas exchange hypoxia-inducible factor
Accès en ligne:	http://www.mdpi.com/1424-8247/8/2/186
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