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Comparative proteomics reveals the mechanism of cyclosporine production and mycelial growth in Tolypocladium inflatum affected by different carbon sources

Cyclosporine A (CsA) is a secondary cyclopeptide metabolite produced by Tolypocladium inflatum that is widely used clinically as an immunosuppressant. CsA production and mycelial growth differed when T. inflatum was cultured in different carbon source media. During early fermentation, CsA was prefer...

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Principais autores: Junqi Wang, Meijie Liu, Chengzhi Mao, Sizhu Li, Jiabao Zhou, Yaqin Fan, Lizhong Guo, Hao Yu, Xiuqing Yang
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2023-12-01
Serier:Frontiers in Microbiology
Fag:
Tolypocladium inflatum
carbon sources
fructose
sucrose
cyclosporine A
mycelium
Online adgang:https://www.frontiersin.org/articles/10.3389/fmicb.2023.1259101/full
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