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Recent advances and expanding applications of organoid models in unveiling drug ADME profiles

Organoids are three-dimensional (3D) in vitro models generated from stem or progenitor cells that closely replicate the structural and functional complexity of human organs. These systems are emerging as powerful tools in pharmacokinetic research, addressing key limitations of traditional models suc...

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Principais autores: Guolei Zhang, Ruifan Zhang, Zihang Shu, Jing Zhao, Lei Yin, Meiyun Shi, Yanshuo Han
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2026-06-01
coleção:Journal of Pharmaceutical Analysis
Assuntos:
Organoids
Pharmacokinetics
ADME
In vitro models
Personalized medicine
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2095177926001310
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