Targeted gene silencing in human embryonic stem cells using cell-penetrating peptide PepFect 14

Abstract Background Human embryonic stem (hES) cells serve as an invaluable tool for research and future medicine, but their transfection often leads to unwanted side effects as the method itself may induce differentiation. On the other hand, RNA interference (RNAi)-based targeted gene silencing is...

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Autors principals:	Egle-Helene Ervin, Martin Pook, Indrek Teino, Valmar Kasuk, Annika Trei, Margus Pooga, Toivo Maimets
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2019-01-01
Col·lecció:	Stem Cell Research & Therapy
Matèries:	Human embryonic stem cells siRNA transfection Cell-penetrating peptide PepFect 14 OCT4 B2M
Accés en línia:	http://link.springer.com/article/10.1186/s13287-019-1144-x
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