Targeted gene silencing in human embryonic stem cells using cell-penetrating peptide PepFect 14

Abstract Background Human embryonic stem (hES) cells serve as an invaluable tool for research and future medicine, but their transfection often leads to unwanted side effects as the method itself may induce differentiation. On the other hand, RNA interference (RNAi)-based targeted gene silencing is...

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Autores principales:	Egle-Helene Ervin, Martin Pook, Indrek Teino, Valmar Kasuk, Annika Trei, Margus Pooga, Toivo Maimets
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	BMC 2019-01-01
Colección:	Stem Cell Research & Therapy
Materias:	Human embryonic stem cells siRNA transfection Cell-penetrating peptide PepFect 14 OCT4 B2M
Acceso en línea:	http://link.springer.com/article/10.1186/s13287-019-1144-x
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