Hydroxyethylamine based analog targets microtubule assembly: an in silico study for anti-cancerous drug development

Abstract Microtubules are dynamic cytoskeletal structures essential for cell architecture, cellular transport, cell motility, and cell division. Due to their dynamic nature, known as dynamic instability, microtubules can spontaneously switch between phases of growth and shortening. Disruptions in mi...

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Autores principales:	Pawan Kumar, Rajni Khan, Basant Narain Singh, Anisha Kumari, Ankit Rai, Anil Kumar Singh, Amresh Prakash, Shashikant Ray
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Nature Portfolio 2024-12-01
Colección:	Scientific Reports
Materias:	Αβ-tubulin MD simulation MM-GBSA
Acceso en línea:	https://doi.org/10.1038/s41598-024-82823-8
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