QR code

Amlexanox: Readthrough Induction and Nonsense-Mediated mRNA Decay Inhibition in a Charcot–Marie–Tooth Model of hiPSCs-Derived Neuronal Cells Harboring a Nonsense Mutation in <i>GDAP1</i> Gene

Nonsense mutations are involved in multiple peripheral neuropathies. These mutations induce the presence of a premature termination codon (PTC) at the mRNA level. As a result, a dysfunctional or truncated protein is synthesized, or even absent linked to nonsense-mediated mRNA degradation (NMD) syste...

Volledige beschrijving

Bewaard in:
Hoofdauteurs: Nesrine Benslimane, Federica Miressi, Camille Loret, Laurence Richard, Angélique Nizou, Ioanna Pyromali, Pierre-Antoine Faye, Frédéric Favreau, Fabrice Lejeune, Anne-Sophie Lia
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: MDPI AG 2023-07-01
Reeks:Pharmaceuticals
Onderwerpen:
GDAP1
CMT disease
nonsense mutation
nonsense-mediated decay (NMD)
readthrough molecules
premature termination codon (PTC)
Online toegang:https://www.mdpi.com/1424-8247/16/7/1034
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items