Insights into the aggregation mechanism of RNA recognition motif domains in TDP-43: a theoretical exploration

The transactive response DNA-binding protein 43 (TDP-43) is associated with several diseases such as amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) due to pathogenic aggregations. In this work, we examined the dimer, tetramer and hexamer models built from the RRM do...

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Hlavní autoři:	Wei Liu, Chaoqun Li, Jiankai Shan, Yan Wang, Guangju Chen
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	The Royal Society 2021-08-01
Edice:	Royal Society Open Science
Témata:	TDP-43 protein RRM1 and RRM2 domains molecular dynamics simulation aggregation
On-line přístup:	https://royalsocietypublishing.org/doi/10.1098/rsos.210160
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