Pause sequences facilitate entry into long-lived paused states by reducing RNA polymerase transcription rates
Transcription elongation by RNA polymerase (RNAP) is interspersed with sequence-dependent pausing which is difficult to study due to spatiotemporal limitations of available methods. Here authors use a high-resolution optical tweezers assay and find that pause sites modify the dynamics of nearly all...
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| Principais autores: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Portfolio
2018-07-01
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| coleção: | Nature Communications |
| Acesso em linha: | https://doi.org/10.1038/s41467-018-05344-9 |
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