Pause sequences facilitate entry into long-lived paused states by reducing RNA polymerase transcription rates

Transcription elongation by RNA polymerase (RNAP) is interspersed with sequence-dependent pausing which is difficult to study due to spatiotemporal limitations of available methods. Here authors use a high-resolution optical tweezers assay and find that pause sites modify the dynamics of nearly all...

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Bibliografische gegevens

Hoofdauteurs:	Ronen Gabizon, Antony Lee, Hanif Vahedian-Movahed, Richard H. Ebright, Carlos J. Bustamante
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	Nature Portfolio 2018-07-01
Reeks:	Nature Communications
Online toegang:	https://doi.org/10.1038/s41467-018-05344-9
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