The progeroid phenotype of Ku80 deficiency is dominant over DNA-PKCS deficiency.
Ku80 and DNA-PKCS are both involved in the repair of double strand DNA breaks via the nonhomologous end joining (NHEJ) pathway. While ku80-/- mice exhibit a severely reduced lifespan and size, this phenotype is less pronounced in dna-pkcs-/- mice. However, these observations are based on independent...
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| Principais autores: | , , , , , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Public Library of Science (PLoS)
2014-01-01
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| Serija: | PLoS ONE |
| Online dostop: | http://europepmc.org/articles/PMC3989187?pdf=render |
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