The progeroid phenotype of Ku80 deficiency is dominant over DNA-PKCS deficiency.
Ku80 and DNA-PKCS are both involved in the repair of double strand DNA breaks via the nonhomologous end joining (NHEJ) pathway. While ku80-/- mice exhibit a severely reduced lifespan and size, this phenotype is less pronounced in dna-pkcs-/- mice. However, these observations are based on independent...
Na minha lista:
| Principais autores: | , , , , , , , , , , , |
|---|---|
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science (PLoS)
2014-01-01
|
| Colecção: | PLoS ONE |
| Acesso em linha: | http://europepmc.org/articles/PMC3989187?pdf=render |
| Tags: |
Sem tags, seja o primeiro a adicionar uma tag!
|