The BAMBOO method for correcting batch effects in high throughput proximity extension assays for proteomic studies

Abstract The proximity extension assay (PEA) enables large-scale proteomic investigations across numerous proteins and samples. However, discrepancies between measurements, known as batch-effects, potentially skew downstream statistical analyses and increase the risks of false discoveries. While imp...

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Bibliografische Detailangaben

Hauptverfasser:	H. M. Smits, E. M. Delemarre, A. Pandit, A. H. Schoneveld, B. Oldenburg, F. van Wijk, S. Nierkens, J. Drylewicz
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Portfolio 2025-01-01
Schriftenreihe:	Scientific Reports
Schlagworte:	Proteomics Large proteomic study Batch effects Batch effects correction Bridging controls
Online-Zugang:	https://doi.org/10.1038/s41598-024-84320-4
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