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A benchmark of batch-effect correction methods for single-cell RNA sequencing data

Abstract Background Large-scale single-cell transcriptomic datasets generated using different technologies contain batch-specific systematic variations that present a challenge to batch-effect removal and data integration. With continued growth expected in scRNA-seq data, achieving effective batch i...

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Bibliografische Detailangaben
Hauptverfasser: Hoa Thi Nhu Tran, Kok Siong Ang, Marion Chevrier, Xiaomeng Zhang, Nicole Yee Shin Lee, Michelle Goh, Jinmiao Chen
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMC 2020-01-01
Schriftenreihe:Genome Biology
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Online-Zugang:https://doi.org/10.1186/s13059-019-1850-9
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