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Metabolic signature and proteasome activity controls synovial migration of CDC42hiCD14+ cells in rheumatoid arthritis

ObjectiveActivation of Rho-GTPases in macrophages causes inflammation and severe arthritis in mice. In this study, we explore if Rho-GTPases define the joint destination of pathogenic leukocytes, the mechanism by which they perpetuate rheumatoid arthritis (RA), and how JAK inhibition mitigates these...

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Wedi'i Gadw mewn:
Prif Awduron: Eric Malmhäll-Bah, Karin M.E. Andersson, Malin C. Erlandsson, Sofia T. Silfverswärd, Rille Pullerits, Maria I. Bokarewa
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Frontiers Media S.A. 2023-08-01
Cyfres:Frontiers in Immunology
Pynciau:
Rho-GTPases
CD14+ cells
synovia
arthritis
oxidative phosphorylation
proteasome
Mynediad Ar-lein:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1187093/full
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