Metabolic signature and proteasome activity controls synovial migration of CDC42hiCD14+ cells in rheumatoid arthritis

ObjectiveActivation of Rho-GTPases in macrophages causes inflammation and severe arthritis in mice. In this study, we explore if Rho-GTPases define the joint destination of pathogenic leukocytes, the mechanism by which they perpetuate rheumatoid arthritis (RA), and how JAK inhibition mitigates these...

Бүрэн тодорхойлолт

Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Eric Malmhäll-Bah, Karin M.E. Andersson, Malin C. Erlandsson, Sofia T. Silfverswärd, Rille Pullerits, Maria I. Bokarewa
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Frontiers Media S.A. 2023-08-01
Цуврал:	Frontiers in Immunology
Нөхцлүүд:	Rho-GTPases CD14+ cells synovia arthritis oxidative phosphorylation proteasome
Онлайн хандалт:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1187093/full
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!