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Influence of Amlodipine Enantiomers on Human Microsomal Cytochromes P450: Stereoselective Time-Dependent Inhibition of CYP3A Enzyme Activity

Amlodipine (AML) is available as a racemate, i.e., a mixture of R- and S-enantiomers. Its inhibitory potency towards nine cytochromes P450 (CYP) was studied to evaluate the drug–drug interactions between the enantiomers. Enzyme inhibition was evaluated using specific CYP substrates in human liver mi...

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Main Authors: Kristyna Krasulova, Ondrej Holas, Pavel Anzenbacher
Format: Artigo
Language:Inglês
Published: MDPI AG 2017-11-01
Series:Molecules
Subjects:
amlodipine
enantiomers
cytochrome P450
drug–drug interactions
enzyme inhibition
stereoselectivity
Online Access:https://www.mdpi.com/1420-3049/22/11/1879
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