Influence of Amlodipine Enantiomers on Human Microsomal Cytochromes P450: Stereoselective Time-Dependent Inhibition of CYP3A Enzyme Activity

Amlodipine (AML) is available as a racemate, i.e., a mixture of R- and S-enantiomers. Its inhibitory potency towards nine cytochromes P450 (CYP) was studied to evaluate the drug–drug interactions between the enantiomers. Enzyme inhibition was evaluated using specific CYP substrates in human liver mi...

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Principais autores:	Kristyna Krasulova, Ondrej Holas, Pavel Anzenbacher
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2017-11-01
coleção:	Molecules
Assuntos:	amlodipine enantiomers cytochrome P450 drug–drug interactions enzyme inhibition stereoselectivity
Acesso em linha:	https://www.mdpi.com/1420-3049/22/11/1879
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