Influence of Amlodipine Enantiomers on Human Microsomal Cytochromes P450: Stereoselective Time-Dependent Inhibition of CYP3A Enzyme Activity

Amlodipine (AML) is available as a racemate, i.e., a mixture of R- and S-enantiomers. Its inhibitory potency towards nine cytochromes P450 (CYP) was studied to evaluate the drug–drug interactions between the enantiomers. Enzyme inhibition was evaluated using specific CYP substrates in human liver mi...

पूर्ण विवरण

ग्रंथसूची विवरण

मुख्य लेखकों:	Kristyna Krasulova, Ondrej Holas, Pavel Anzenbacher
स्वरूप:	Artigo
भाषा:	Inglês
प्रकाशित:	MDPI AG 2017-11-01
श्रृंखला:	Molecules
विषय:	amlodipine enantiomers cytochrome P450 drug–drug interactions enzyme inhibition stereoselectivity
ऑनलाइन पहुंच:	https://www.mdpi.com/1420-3049/22/11/1879
टैग:	टैग जोड़ें कोई टैग नहीं, इस रिकॉर्ड को टैग करने वाले पहले व्यक्ति बनें!