Coculture of bovine cartilage with synovium and fibrous joint capsule increases aggrecanase and matrix metalloproteinase activity

Abstract Background A hallmark of osteoarthritis is increased proteolytic cleavage of aggrecan. Cross talk between cartilage and the synovium + joint capsule (SJC) can drive cartilage degradation by activating proteases in both tissues. We investigated aggrecan proteolysis patterns in cartilage expl...

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Váldodahkkit:	Per Swärd, Yang Wang, Maria Hansson, L. Stefan Lohmander, Alan J. Grodzinsky, André Struglics
Materiálatiipa:	Artigo
Giella:	Inglês
Almmustuhtton:	BMC 2017-07-01
Ráidu:	Arthritis Research & Therapy
Fáttát:	Aggrecan Cartilage injury Fibrous joint capsule Knee injury Synovium Metalloproteinases
Liŋkkat:	http://link.springer.com/article/10.1186/s13075-017-1318-9
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