Coculture of bovine cartilage with synovium and fibrous joint capsule increases aggrecanase and matrix metalloproteinase activity

Abstract Background A hallmark of osteoarthritis is increased proteolytic cleavage of aggrecan. Cross talk between cartilage and the synovium + joint capsule (SJC) can drive cartilage degradation by activating proteases in both tissues. We investigated aggrecan proteolysis patterns in cartilage expl...

Celý popis

Podrobná bibliografie

Hlavní autoři:	Per Swärd, Yang Wang, Maria Hansson, L. Stefan Lohmander, Alan J. Grodzinsky, André Struglics
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2017-07-01
Edice:	Arthritis Research & Therapy
Témata:	Aggrecan Cartilage injury Fibrous joint capsule Knee injury Synovium Metalloproteinases
On-line přístup:	http://link.springer.com/article/10.1186/s13075-017-1318-9
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!