Combined nanopore adaptive sequencing and enzyme-based host depletion efficiently enriched microbial sequences and identified missing respiratory pathogens

Abstract Background Enzyme-based host depletion significantly improves the sensitivity of clinical metagenomics. Recent studies found that real-time adaptive sequencing of DNA molecules was achieved using a nanopore sequencing machine, which enabled effective enrichment of microbial sequences. Howev...

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Autors principals:	Mingyu Gan, Bingbing Wu, Gangfeng Yan, Gang Li, Li Sun, Guoping Lu, Wenhao Zhou
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2021-10-01
Col·lecció:	BMC Genomics
Matèries:	Metagenomics Nanopore adaptive sequencing Host depletion Microbe enrichment
Accés en línia:	https://doi.org/10.1186/s12864-021-08023-0
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