Combined nanopore adaptive sequencing and enzyme-based host depletion efficiently enriched microbial sequences and identified missing respiratory pathogens

Abstract Background Enzyme-based host depletion significantly improves the sensitivity of clinical metagenomics. Recent studies found that real-time adaptive sequencing of DNA molecules was achieved using a nanopore sequencing machine, which enabled effective enrichment of microbial sequences. Howev...

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Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Mingyu Gan, Bingbing Wu, Gangfeng Yan, Gang Li, Li Sun, Guoping Lu, Wenhao Zhou
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	BMC 2021-10-01
Цуврал:	BMC Genomics
Нөхцлүүд:	Metagenomics Nanopore adaptive sequencing Host depletion Microbe enrichment
Онлайн хандалт:	https://doi.org/10.1186/s12864-021-08023-0
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!