Prognostic and immunological significance of key gluconeogenesis regulators, PCK1 and PCK2, in human cancers especially kidney renal clear cell carcinoma: Insights from pan-cancer analysis, PCKs signature construction, and in vitro experiments

Background: Metabolic reprogramming is a significant feature of tumor cells, and targeting metabolic pathways has become a viable strategy for cancer therapy. Gluconeogenesis is essential to glucose metabolism, with phosphoenolpyruvate carboxykinase 1 (PCK1) and phosphoenolpyruvate carboxykinase 2 (...

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主要な著者:	Zebin Shang, Haonan Zhao, Tianhao Yang, Xuewen Xue, Binggang Zhao, Yujie Sun
フォーマット:	Artigo
言語:	Inglês
出版事項:	Elsevier 2023-09-01
シリーズ:	Journal of Radiation Research and Applied Sciences
主題:	Gluconeogenesis PCK1 PCK2 Pan-cancer Tumor microenvironment (TME) Adrenocortical carcinoma (ACC)
オンライン･アクセス:	http://www.sciencedirect.com/science/article/pii/S1687850723000924
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