Resection and repair of a Cas9 double-strand break at CTG trinucleotide repeats induces local and extensive chromosomal deletions.
Microsatellites are short tandem repeats, ubiquitous in all eukaryotes and represent ~2% of the human genome. Among them, trinucleotide repeats are responsible for more than two dozen neurological and developmental disorders. Targeting microsatellites with dedicated DNA endonucleases could become a...
Na minha lista:
| Principais autores: | , , , , , |
|---|---|
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science (PLoS)
2020-07-01
|
| Colecção: | PLoS Genetics |
| Acesso em linha: | https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1008924&type=printable |
| Tags: |
Sem tags, seja o primeiro a adicionar uma tag!
|