Ethidium Bromide Modifies The Agarose Electrophoretic Mobility of CAG•CTG Alternative DNA Structures Generated by PCR

The abnormal expansion of unstable simple sequence DNA repeats can cause human disease through a variety of mechanisms, including gene loss-of-function, toxic gain-of-function of the encoded protein and toxicity of the repeat-containing RNA transcript. Disease-associated unstable DNA repeats display...

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Autores principales:	Mário Gomes-Pereira, Darren G. Monckton
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Frontiers Media S.A. 2017-05-01
Colección:	Frontiers in Cellular Neuroscience
Materias:	trinucleotide DNA repeat myotonic dystrophy non-B DNA ethidium bromide PCR agarose
Acceso en línea:	http://journal.frontiersin.org/article/10.3389/fncel.2017.00153/full
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