QR-Code

Progranulin loss results in sex-dependent dysregulation of the peripheral and central immune system

IntroductionProgranulin (PGRN) is a secreted glycoprotein, the expression of which is linked to several neurodegenerative diseases. Although its specific function is still unclear, several studies have linked it with lysosomal functions and immune system regulation. Here, we have explored the role o...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Madelyn C. Houser, Oihane Uriarte Huarte, Rebecca L. Wallings, Cody E. Keating, Kathryn P. MacPherson, Mary K. Herrick, George T. Kannarkat, Sean D. Kelly, Jianjun Chang, Nicholas H. Varvel, Jessica E. Rexach, Malú Gámez Tansey
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2022-12-01
Schriftenreihe:Frontiers in Immunology
Schlagworte:
progranulin
peripheral-brain crosstalk
microglia
monocytes
T cells
GPNMB
Online-Zugang:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1056417/full
Tags: Tag hinzufügen
Keine Tags, Fügen Sie das erste Tag hinzu!

Ähnliche Einträge