Human selenoprotein P and S variant mRNAs with different numbers of SECIS elements and inferences from mutant mice of the roles of multiple SECIS elements

Dynamic redefinition of the 10 UGAs in human and mouse selenoprotein P (Sepp1) mRNAs to specify selenocysteine instead of termination involves two 3′ UTR structural elements (SECIS) and is regulated by selenium availability. In addition to the previously known human Sepp1 mRNA poly(A) addition site...

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Detalhes bibliográficos

Principais autores:	Sen Wu, Marco Mariotti, Didac Santesmasses, Kristina E. Hill, Janinah Baclaocos, Estel Aparicio-Prat, Shuping Li, John Mackrill, Yuanyuan Wu, Michael T. Howard, Mario Capecchi, Roderic Guigó, Raymond F. Burk, John F. Atkins
Formato:	Artigo
Idioma:	Inglês
Publicado em:	The Royal Society 2016-01-01
coleção:	Open Biology
Assuntos:	codon redefinition ribosome specialization selenocysteine selenoprotein p selenoprotein s
Acesso em linha:	https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.160241
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