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Glycyrrhetinic Acid-Functionalized Mesoporous Silica Nanoparticles for the Co-Delivery of DOX/CPT-PEG for Targeting HepG2 Cells

A pH-triggered mesoporous silica nanoparticle (MSN)-based nano-vehicle for the dual delivery of doxorubicin (DOX)/camptothecin-PEG (CPT-PEG) has been prepared. To enhance its selectivity, the nanoparticles were decorated with glycyrrhetinic acid (GA) to target HepG2 cells. The highly insoluble CPT w...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Gabriel Martínez-Edo, Cristina Fornaguera, Salvador Borrós, David Sánchez-García
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI AG 2020-11-01
Schriftenreihe:Pharmaceutics
Schlagworte:
mesoporous silica nanoparticles
dual release
doxorubicin
camptothecin
anticancer drugs
combination therapy
Online-Zugang:https://www.mdpi.com/1999-4923/12/11/1048
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