LRP-1 and LRP-2 receptors function in the membrane neuron. Trafficking mechanisms and proteolytic processing in Alzheimer’s disease

Low density lipoprotein receptor-related protein (LRP) belongs to the low-density lipoprotein receptor family, generally recognized as cell surface endocytic receptors, which bind and internalize extracellular ligands for degradation in lysosomes. Neurons require cholesterol to function and keep the...

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Hlavní autoři:	Carlos eSpuch, Saida eOrtolano, Carmen eNavarro
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2012-07-01
Edice:	Frontiers in Physiology
Témata:	Lipoproteins Neurodegenerative Diseases Alzheimer’s disease LRP1 Intracellular domain LRP2
On-line přístup:	http://journal.frontiersin.org/Journal/10.3389/fphys.2012.00269/full
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