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LRP-1 and LRP-2 receptors function in the membrane neuron. Trafficking mechanisms and proteolytic processing in Alzheimer’s disease

Low density lipoprotein receptor-related protein (LRP) belongs to the low-density lipoprotein receptor family, generally recognized as cell surface endocytic receptors, which bind and internalize extracellular ligands for degradation in lysosomes. Neurons require cholesterol to function and keep the...

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Principais autores: Carlos eSpuch, Saida eOrtolano, Carmen eNavarro
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2012-07-01
Serier:Frontiers in Physiology
Fag:
Lipoproteins
Neurodegenerative Diseases
Alzheimer’s disease
LRP1
Intracellular domain
LRP2
Online adgang:http://journal.frontiersin.org/Journal/10.3389/fphys.2012.00269/full
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