Lipid-regulated degradation of HMG-CoA reductase and Insig-1 through distinct mechanisms in insect cells

In mammalian cells, levels of the integral membrane proteins 3-hydroxy-3-methylglutaryl-CoA reductase and Insig-1 are controlled by lipid-regulated endoplasmic reticulum-associated degradation (ERAD). The ERAD of reductase slows a rate-limiting step in cholesterol synthesis and results from sterol-i...

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Detalhes bibliográficos

Principais autores:	Rebecca A. Faulkner, Andrew D. Nguyen, Youngah Jo, Russell A. DeBose-Boyd
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2013-04-01
coleção:	Journal of Lipid Research
Assuntos:	endoplasmic reticulum-associated degradation lipid metabolism ubiquitin ligase cytosolic dislocation 3-hydroxy-3-methylglutaryl-CoA
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S0022227520422059
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