Depletion of essential isoprenoids and ER stress induction following acute liver-specific deletion of HMG-CoA reductase

HMG-CoA reductase (Hmgcr) is the rate-limiting enzyme in the mevalonate pathway and is inhibited by statins. In addition to cholesterol, Hmgcr activity is also required for synthesizing nonsterol isoprenoids, such as dolichol, ubiquinone, and farnesylated and geranylgeranylated proteins. Here, we in...

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Autores principales:	Marco De Giorgi, Kelsey E. Jarrett, Jason C. Burton, Alexandria M. Doerfler, Ayrea Hurley, Ang Li, Rachel H. Hsu, Mia Furgurson, Kalyani R. Patel, Jun Han, Christoph H. Borchers, William R. Lagor
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Elsevier 2020-12-01
Colección:	Journal of Lipid Research
Materias:	cholesterol synthesis and regulation liver endoplasmic reticulum animal models 3-hydroxy-3-methylglutaryl-coenzyme A adeno-associated virus
Acceso en línea:	http://www.sciencedirect.com/science/article/pii/S002222752060027X
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