Amplification of the gene for SCAP, coupled with Insig-1 deficiency, confers sterol resistance in mutant Chinese hamster ovary cells

The endoplasmic reticulum membrane proteins Insig-1 and Insig-2 limit cholesterol synthesis, in part through their sterol-dependent binding to sterol-regulatory element binding protein (SREBP) cleavage-activating protein (SCAP). This binding prevents proteolytic processing of SREBPs, membrane-bound...

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Principais autores:	Peter C.W. Lee, Pingsheng Liu, Wei-Ping Li, Russell A. DeBose-Boyd
Formato:	Artigo
Idioma:	Inglês
Publicado:	Elsevier 2007-09-01
Series:	Journal of Lipid Research
Assuntos:	cholesterol homeostasis endoplasmic reticulum-Golgi translocation ubiquitination somatic cell genetics mutagenesis sterol-sensing domain
Acceso en liña:	http://www.sciencedirect.com/science/article/pii/S0022227520424824
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