The human microbiome-derived antimicrobial lugdunin self-regulates its biosynthesis by a feed-forward mechanism

ABSTRACT Many human microbiome members inhibit bacterial competitors by production of antimicrobial compounds whose expression needs to be tightly controlled to balance the costs and benefits of compound biosynthesis. The nasal commensal Staphylococcus lugdunensis outcompetes Staphylococcus aureus u...

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Egile Nagusiak:	Leonie Reetz, Lukas Schulze, Thales Kronenberger, Khaled A. Selim, Timm Schaefle, Taulant Dema, Alexander Zipperer, Jens Mößner, Antti Poso, Stephanie Grond, Andreas Peschel, Bernhard Krismer
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	American Society for Microbiology 2025-04-01
Saila:	mBio
Gaiak:	coagulase-negative Staphylococci gene regulation lugdunin protein modeling biosynthetic gene cluster
Sarrera elektronikoa:	https://journals.asm.org/doi/10.1128/mbio.03571-24
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