The human microbiome-derived antimicrobial lugdunin self-regulates its biosynthesis by a feed-forward mechanism

ABSTRACT Many human microbiome members inhibit bacterial competitors by production of antimicrobial compounds whose expression needs to be tightly controlled to balance the costs and benefits of compound biosynthesis. The nasal commensal Staphylococcus lugdunensis outcompetes Staphylococcus aureus u...

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Autores principales:	Leonie Reetz, Lukas Schulze, Thales Kronenberger, Khaled A. Selim, Timm Schaefle, Taulant Dema, Alexander Zipperer, Jens Mößner, Antti Poso, Stephanie Grond, Andreas Peschel, Bernhard Krismer
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	American Society for Microbiology 2025-04-01
Colección:	mBio
Materias:	coagulase-negative Staphylococci gene regulation lugdunin protein modeling biosynthetic gene cluster
Acceso en línea:	https://journals.asm.org/doi/10.1128/mbio.03571-24
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