The microbiome-derived antibacterial lugdunin acts as a cation ionophore in synergy with host peptides

ABSTRACT Lugdunin is a microbiome-derived antibacterial agent with good activity against Gram-positive pathogens in vitro and in animal models of nose colonization and skin infection. We have previously shown that lugdunin depletes bacterial energy resources by dissipating the membrane potential of...

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Autors principals:	Anne Berscheid, Jan Straetener, Nadine A. Schilling, Dominik Ruppelt, Martin C. Konnerth, Birgit Schittek, Bernhard Krismer, Andreas Peschel, Claudia Steinem, Stephanie Grond, Heike Brötz-Oesterhelt
Format:	Artigo
Idioma:	Inglês
Publicat:	American Society for Microbiology 2024-09-01
Col·lecció:	mBio
Matèries:	Staphylococcus aureus antibacterial agent natural product bacteriocin mechanism of action membrane potential
Accés en línia:	https://journals.asm.org/doi/10.1128/mbio.00578-24
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