The microbiome-derived antibacterial lugdunin acts as a cation ionophore in synergy with host peptides

ABSTRACT Lugdunin is a microbiome-derived antibacterial agent with good activity against Gram-positive pathogens in vitro and in animal models of nose colonization and skin infection. We have previously shown that lugdunin depletes bacterial energy resources by dissipating the membrane potential of...

Täydet tiedot

Bibliografiset tiedot

Päätekijät:	Anne Berscheid, Jan Straetener, Nadine A. Schilling, Dominik Ruppelt, Martin C. Konnerth, Birgit Schittek, Bernhard Krismer, Andreas Peschel, Claudia Steinem, Stephanie Grond, Heike Brötz-Oesterhelt
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	American Society for Microbiology 2024-09-01
Sarja:	mBio
Aiheet:	Staphylococcus aureus antibacterial agent natural product bacteriocin mechanism of action membrane potential
Linkit:	https://journals.asm.org/doi/10.1128/mbio.00578-24
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