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Propagation of SARS-CoV-2 in Calu-3 Cells to Eliminate Mutations in the Furin Cleavage Site of Spike

SARS-CoV-2 pathogenesis, vaccine, and therapeutic studies rely on the use of animals challenged with highly pathogenic virus stocks produced in cell cultures. Ideally, these virus stocks should be genetically and functionally similar to the original clinical isolate, retaining wild-type properties t...

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Hoofdauteurs: John James Baczenas, Hanne Andersen, Sujatha Rashid, David Yarmosh, Nikhita Puthuveetil, Michael Parker, Rebecca Bradford, Clint Florence, Kimberly J. Stemple, Mark G. Lewis, Shelby L. O’Connor
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: MDPI AG 2021-12-01
Reeks:Viruses
Onderwerpen:
SARS-CoV-2
polymorphisms
Calu-3
stock preparation
Online toegang:https://www.mdpi.com/1999-4915/13/12/2434
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