Spike conformational and glycan heterogeneity associated with furin cleavage causes incomplete neutralization of SARS-CoV-2

Abstract SARS-CoV-2 Spike - the sole neutralization target, is highly resilient to the immune pressure driving genetic evolution. While potency and breadth of neutralization are widely studied, the incomplete neutralization - the mechanism of resistance without needing genetic change - remains unexp...

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Hlavní autoři:	Sahil Kumar, Rathina Delipan, Chanchal Sharma, Jyoti Jadoun, Kawkab Kanjo, Randhir Singh, Raju Rajmani, Suprit Deshpande, Rajesh Pandey, Krishan G. Thakur, Jayanta Bhattacharya, Rogier W. Sanders, Marit J. van Gils, Raghavan Varadarajan, Rajesh P. Ringe
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Portfolio 2025-11-01
Edice:	Nature Communications
On-line přístup:	https://doi.org/10.1038/s41467-025-65099-y
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