Vero cell-adapted SARS-CoV-2 strain shows increased viral growth through furin-mediated efficient spike cleavage

ABSTRACTSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) utilizes several host proteases to cleave the spike (S) protein to enter host cells. SARS-CoV-2 S protein is cleaved into S1 and S2 subunits by furin, which is closely involved in the pathogenicity of SARS-CoV-2. However, the effec...

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मुख्य लेखकों:	Shohei Minami, Tomohiro Kotaki, Yusuke Sakai, Shinya Okamura, Shiho Torii, Chikako Ono, Daisuke Motooka, Rina Hamajima, Ryotaro Nouda, Jeffery A. Nurdin, Moeko Yamasaki, Yuta Kanai, Hirotaka Ebina, Yusuke Maeda, Toru Okamoto, Taro Tachibana, Yoshiharu Matsuura, Takeshi Kobayashi
स्वरूप:	Artigo
भाषा:	Inglês
प्रकाशित:	American Society for Microbiology 2024-04-01
श्रृंखला:	Microbiology Spectrum
विषय:	severe acute respiratory syndrome virus-2 (SARS-CoV-2) spike (S) protein viral replication infection pathogenicity
ऑनलाइन पहुंच:	https://journals.asm.org/doi/10.1128/spectrum.02859-23
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