Vero cell-adapted SARS-CoV-2 strain shows increased viral growth through furin-mediated efficient spike cleavage

ABSTRACTSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) utilizes several host proteases to cleave the spike (S) protein to enter host cells. SARS-CoV-2 S protein is cleaved into S1 and S2 subunits by furin, which is closely involved in the pathogenicity of SARS-CoV-2. However, the effec...

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Detalhes bibliográficos

Principais autores:	Shohei Minami, Tomohiro Kotaki, Yusuke Sakai, Shinya Okamura, Shiho Torii, Chikako Ono, Daisuke Motooka, Rina Hamajima, Ryotaro Nouda, Jeffery A. Nurdin, Moeko Yamasaki, Yuta Kanai, Hirotaka Ebina, Yusuke Maeda, Toru Okamoto, Taro Tachibana, Yoshiharu Matsuura, Takeshi Kobayashi
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology 2024-04-01
coleção:	Microbiology Spectrum
Assuntos:	severe acute respiratory syndrome virus-2 (SARS-CoV-2) spike (S) protein viral replication infection pathogenicity
Acesso em linha:	https://journals.asm.org/doi/10.1128/spectrum.02859-23
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