The ApoA-IV–LRP1 Signaling Axis: A Novel Insulin-Independent Pathway for the Suppression of Diabetic Hyperglucagonemia

Apolipoprotein A-IV (ApoA-IV) is a glycoprotein secreted by the small intestine to regulate lipid metabolism and satiety. Its role in insulin-independent glucose homeostasis remains largely unknown. In this study, we demonstrate that intestinal ApoA-IV overexpression significantly attenuates diet-in...

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Principais autores:	Min Liu, Xenia Davis, Chih-Wei Ko, Ling Shen, Maureen Fitzgerald, Chunmin C. Lo, Patrick Tso
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2026-07-01
coleção:	Cells
Assuntos:	Apolipoprotein A-IV diet-induced obesity streptozotocin glucagon LRP1 gluconeogenesis
Acesso em linha:	https://www.mdpi.com/2073-4409/15/13/1229
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