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A thumbwheel mechanism for APOA1 activation of LCAT activity in HDL[S]

APOA1 is the most abundant protein in HDL. It modulates interactions that affect HDL';s cardioprotective functions, in part via its activation of the enzyme, LCAT. On nascent discoidal HDL, APOA1 comprises 10 α-helical repeats arranged in an anti-parallel stacked-ring structure that encapsulates a l...

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Principais autores: Allison L. Cooke, Jamie Morris, John T. Melchior, Scott E. Street, W.Gray Jerome, Rong Huang, Andrew B. Herr, Loren E. Smith, Jere P. Segrest, Alan T. Remaley, Amy S. Shah, Thomas B. Thompson, W.Sean Davidson
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2018-01-01
coleção:Journal of Lipid Research
Assuntos:
apolipoproteins
cholesterol metabolism
lecithin:cholesterol acyltransferase
high density lipoprotein metabolism
high density lipoprotein
proteomics
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S0022227520330819
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